H. Ouyang*a (Dr)

a Xi’an International Medical Center hospital, Xi’an, CHINA

* ouyhf@hotmail.com

Background: Peripheral pulmonary lesions are very common in clinical settings. Acquiring adequate tissue sample remains a challenge. It is assumed that the combination of 1.1mm probe transbronchial cryobiopsy, ultrathin bronchoscope and Lungpoint navigation could increase the diagnostic value of peripheral pulmonary lesions. Objective: The aim of this study is to evaluate the efficacy and safety of transbronchial cryobiopsy using 1.1mm probe combined with ultrathin bronchoscope and Lungpoint navigation for peripheral pulmonary lesions. Methods: We retrospectively analyzed 106 patients with who underwent 1.1mm probe transbronchial cryobiopsy with ultrathin bronchoscope and Lungpoint navigation from March 2021 to May 2021 in Xi’an International Medical Center hospital. We collected the baseline information of participants, reported diagnostic yield and complications, and analyzed factors may have affected the diagnostic yield. Results: A total of 106 peripheral pulmonary lesions, with an average diameter of 20.11±12.23 mm, underwent the procedure, and the diagnostic yield was 90.11% (96/106). Of the 96 lesions diagnosed by this procedure, 45 were lung cancers, 5 were other malignancies, 9 were atypical adenomatous hyperplasia, 5 were tuberculosis, 6 were organizing pneumonia, 5 were pulmonary interstitial fibrosis, 21 were acute and chronic pneumonia. The remaining 10 undiagnosed lesions were diagnosed by re-examination with cryobiopsy, TTNB or Lungpoint-TBNA. The diagnostic yield was unchanged by factors including rEBUS findings (within, adjacent to) and lobe localization. There was no presentation of pneumothorax or severe hemorrhage. Conclusions: The transbronchial cryobiopsy using 1.1mm probe combined with ultrathin bronchoscope and Lungpoint navigation is feasible, safe, and has a high diagnostic yield in the diagnosis of peripheral pulmonary lesions.

Disclosure of funding source(s): none