Radial probe endobronchial ultrasound-guided transbronchial lung cryobiopsy using 1.1 mm flexible cryoprobe for peripheral lesions.
D. Park*a (Prof)
a Chungnam National University Hospital, Daejeon, KOREA, REPUBLIC OF
Background: Cryobiopsy is known to improve the diagnostic yield of peripheral lung lesions (PPL) (1). It has also been reported that cryobiopsy using a guide sheath (GS) is significantly associated with increased diagnostic yield during radial probe endobronchial ultrasound (R-EBUS)-guided transbronchial lung cryobiopsy (TBLC) (2). We aimed to investigate whether the use of 1.1 mm flexible cryoprobe and GS improves the diagnostic accuracy for PPL.
Methods: Data from patients who underwent R-EBUS-guided TBLC at Chungnam National University Hospital from August 2021 to April 2022 were retrospectively analyzed.
Results: A total of 210 lesions were analyzed. The diagnostic yields of forceps biopsy and cryobiopsy were 57.3% and 79.2%, respectively, and the total diagnostic yield was 85.3% (p<0.001). The diagnostic yields of forceps biopsy and cryobiopsy for malignant lesions were 62.4% and 94.6%, respectively (p<0.001). Bleeding occurred in 62 patients (35.1%), and among them, there were 13 (10.6%) clinically significant bleeding (moderate bleeding or severe) cases. There were no severe or life-threatening bleedings.
Conclusions: R-EBUS-guided TBLC using 1.1 mm flexible cryoprobe and GS improves the diagnostic accuracy for PPL.
- Kho SS, Chan SK, Yong MC, Tie ST. Performance of transbronchial cryobiopsy in eccentrically and adjacently orientated radial endobronchial ultrasound lesions. ERJ Open Res. 2019 Oct 21;5(4):00135-2019.
- Nasu S, Okamoto N, Suzuki H, Shiroyama T, Tanaka A, Samejima Y, Kanai T, Noda Y, Morita S, Morishita N, Ueda K, Kawahara K, Hirashima T. Comparison of the Utilities of Cryobiopsy and Forceps Biopsy for Peripheral Lung Cancer. Anticancer Res. 2019 Oct;39(10):5683-5688.
Disclosure of funding source(s): none