Clinical study of airway stent implantation in the treatment of patients with malignant central airway obstruction
Y. Xinga (Ms), J. Jiang*a (Prof)
a Department of Pulmonary and Critical Care Medicine, Dushu Lake Hospital Affiliated to Soochow University, Suzhou, CHINA
[Abstract] Objective To determine the clinical features and long-term results related to the improved prognosis of patients with malignant central airway obstruction (MCAO) after airway stent implantation. Methods A retrospective analysis of all patients who underwent stent placement for MCAO in our hospital from January 2013 to April 2020. Data were collected for each patient, including baseline data, clinical characteristics, laboratory test data, stent implantation data, treatment and survival after stent implantation. The survival rates were compared using Log-rank tests. Potential prognostic factors were identified using multivariate Cox hazard regression models. Results Total 98 consecutive patients who underwent airway stent placement due to MCAO were included in this study. Lung cancer (53/98, 54.08%), esophageal cancer (22/98, 22.45%) and thyroid cancer (3/98, 3.06%) were the main common diseases that caused MCAO in this study. The median survival time of these patients after airway stent placement was 5.5 months. Univariate analysis showed that primary disease, ECOG PS score, stent site, hemoglobin (Hb), albumin (ALB) and serum lactate dehydrogenase (LDH) were related to the survival rate of MCAO patients (P<0.05). The Cox risk regression model showed that the ECOG PS score (OR=3.468, 95%CI=1.426-8.432, P=0.006) and the stent site (OR=1.544, 95%CI=1.057-2.255, P=0.025) were significantly related to survival rate. Conclusions The survival rate of MCAO patients after airway stenting is related to the ECOG PS score score prior to the stenting and the site of stent placement.
[Key words] Airway stent implantation; Malignant central airway obstruction; Cancer; Survival; Prognostic factors
Disclosure of funding source(s): none