Photodynamic Therapy (PDT) For Advanced Lung Cancer With Airway Stenosis：
X. Xie*a (Prof), X. Lia (Prof), X. Lia (Prof), X. Wanga (Prof), J. Luoa (Prof), Z. Hea (Mrs), J. Liua (Mrs)
a The First People's Hospital of Neijiang, Neijiang, CHINA
* xiufangxie84@163.com
Objectives: to assess the effectiveness and safety of Photodynamic Therapy for Advanced Lung Cancer with Airway Stenosis
METHODS:
advanced lung cancer with Airway Stenosis can be treated palliatively with photodynamic therapy (PDT) combined with argon plasma coagulation(APC) or Airway stenting to remove central and peripheral (lobar or segmental bronchi) bronchial stenosis and obstruction. We present data for 4 patients with advanced non-small cell lung carcinomas in whom curative operations were contraindicated, who underwent PDT combined with APC or Airway stenting for local control of the intraluminal lesions.
Results:
In this single-institution study, The mean age was 73 years (range, 57-85 years), and the stages of cancer were IIIC-IV. The median stenosis rates before treatment, one week post-treatment, and one month post-treatment were 70% (range, 60%-90%), 15% (range, 10%-35%), and 15% (range 15%-60%), respectively. an objective response was evidenced by the substantial increase in the openings of the bronchial lumen。all patients experienced improved symptoms and quality of life at one week after treatment; The overall response rate of short-term was 100%. One patient had mild photoallergic reaction, which characterized by photosensitive dermatitis such as pruritus, Dyspnea was aggravated in 1 patient due to exfoliation of necrotic tissue and airway blockage, None of the 4 patients had PDT-related morbidity or mortality.
Conclusion：Photodynamic therapy is an effective technique for advanced lung cancer causing tracheobronchial obstruction. With debulking endobronchial tumors over an acceptably short time-course; and PDT with other therapy was useful and safe for the treatment of bronchial obstruction.
Disclosure of funding source(s): none