Y. Wang*a (Dr)

a Department of Pulmonary and Critical Care Medicine, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, CHINA

* 765804939@qq.com

Tracheoesophageal fistula(TEF) is a refractory clinical complication, commonly seen after esophageal cancer or lung cancer surgery, with extremely high mortality and poor prognosis. Aspiration pneumonia is the main complication of TEF. There are various causes of aspiration pneumonia. The clinical manifestations of aspiration pneumonia caused by different airway inhalations are different.


To explore the effect of different dietary patterns on TEF aspiration pneumonia and the source of TEF airway reflux


Six experimental beagle dogs were used, numbered 2101-2103, 3101-3103. Using the method of mid-neck incision. The Medtronic aortic punch was used to construct the tracheal and esophageal fistulas. After the completion of construction, 2101-2103 animals were fed by nasogastric feeding tube, and 3101-3103 animals were fed by intravenous nutrition. The airway secretions and inhalations were observed by bronchoscopy within a one-week observation period, and the properties of secretions and inhalations were recorded. After the observation, the animals were sacrificed and the animals were dissected to observe the source of inhalation


  1. Compared with intravenous nutrition, although the nasogastric feeding tube can effectively cross the fistula site, the flow diet causes more airway aspiration and airway secretion than intravenous nutrition, and the anatomical results show that the flow dietLung inflammation was more severe in diet animals, with smaller areas of lung consolidation
  2. According to our results, the main source of airway inhalation is the reflux of gastric contents. The properties of these substances are similar, and in the case of intravenous nutrition, there is still a certain risk of airway aspiration due to gastric secretion.


Compared with nasogastric feeding tube flow diet, intravenous nutrition can better relieve TEF airway content accumulation and aspiration pneumonia. At the same time, the main source of intra-airway reflux aspiration is gastric secretion.

Disclosure of funding source(s): none