H. Anh Duc*a (Dr), NQ. Chaub (Prof), VV. Giapa (Prof), M. Hashimotoc (Dr)

a Bach Mai hospital, Hanoi, VIET NAM ; b Tâm Anh general hospital, Hanoi, VIET NAM ; c National Center for Global Health and Medicine, Tokyo, JAPAN

* hoanganhduc@hmu.edu.vn

Introduction: Mediastinal lesions such as tumors, lymph nodes may be primary or secondary lesions. Diagnosis and evaluation of these lesions have an important role in the treatment and prognosis, as in the case of mediastinal tumor, metastatic mediastinal lymph node. Difficulties on etiologic diagnosis due to inaccessible locations and previous invasive procedure with high risk of complication: thoracoscopy, mediastinoscopy, computed tomography-guided lung biopsy. Endobronchial ultrasound bronchoscopy (EBUS) is a procedure of bronchoscopy combined with ultrasonic bronchial probe to evaluate as well as access to structures (tumors, lymph node).

Patients and Method: Pro-retrospective study was performed on 28 patients diagnosed with mediastinal tumor, lymph nodes undergoing endobronchial ultrasound bronchoscopy to biopsy at Respiratory Center, Bach Mai Hospital from July 2017 to August 2018. Research parameters have been collected before, during and after the intervention: clinical parameters (age, gender, length of hospital stay); parameters during procedure (biopsy location, complications) cytology and histopathology results.

Results: The mean age of the study population was 58, 6 years, female / male ratio was 1/6, mean hospitalization length was 11.6 days, and 19/28 study patients had a history of smoking. Biopsy sites of lymph node station were station 2 (14.3%); station 4 (64.3%): station 7 (32.1%); station 10 (7.1%); station 11 (3.5%). The cytological results showed that 7/28 patients had cancer cells, 2 necrotizing inflammation and 1 granuloma. Histopathological results: 39, 3% of patients (11/28) had cancer diagnosis (including epithelial carcinoma, small cell carcinoma, non-small cell carcinoma, squamous cell carcinoma, carcinoma); 7.1% were granuloma (2/28); 7.1% (2/28) were lymphoid inflamed lymph nodes; 28.5% (8/28) were chronic inflammatory lesions; 3/28 cases cannot be obtained the sample for histopathology. After intervention, the complication rate was 0%.

Conclusion: Endobronchial ultrasound bronchoscopy (EBUS) showed the important role and the safety in the etiologic diagnosis of mediastinal tumor and lymp node.

Disclosure of funding source(s): none